Cancer Genetics Guidelines

Hereditary cancer risk assessment and referral guidance for clinicians

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• Overview
  • About
  • User Guide
  • Important Notes
  • Disclaimer

• Risk Assessment Tool
  • Patient With Cancer Diagnosis
    • Multiple Cancer/Tumour Types
    • Breast Cancer
      • Breast Cancer - Conditions to consider
      • Female Breast Cancer (unilateral)
      • Female Breast Cancer (bilateral)
      • Male Breast Cancer
    • Gastrointestinal Cancer
      • Colorectal Cancer
        • Colorectal Cancer - Conditions to consider
        • Colorectal Cancer
      • Liver Cancer
      • Oesophagogastric Cancer
        • Oesophagogastric Cancer - Conditions to consider
        • Oesophagogastric Cancer
      • Pancreatobiliary Cancer
        • Pancreatobiliary Cancer - Conditions to consider
        • Pancreatobiliary Cancer
      • Small Bowel Cancer
        • Small Bowel Cancer - Conditions to consider
        • Small Bowel Cancer
    • Lung Cancer
    • Gynaecological Cancer
      • Cervical Cancer
      • Endometrial Cancer
        • Endometrial Cancer - Conditions to consider
        • Endometrial Cancer
      • Ovarian, Fallopian tube or Primary Peritoneal Cancer
        • Ovarian, Fallopian tube or Primary Peritoneal Cancer - Conditions to consider
        • Ovarian, Fallopian tube or Primary Peritoneal Cancer
    • Genitourinary Cancer
      • Prostate Cancer
        • Prostate Cancer - Conditions to consider
        • Prostate Cancer
      • Renal Cell Cancer
        • Renal Cell Cancer - Conditions to consider
        • Renal Cell Cancer
      • Urinary Tract Cancer
        • Urinary Tract Cancer - Conditions to consider
        • Urinary Tract Cancer
    • Haematological Cancer
    • Skin Cancer/Tumour
      • Skin Cancer/Tumour - Conditions to consider
      • Skin Cancer/Tumour
    • Endocrine Cancer/Tumour
      • Adrenocortical Cancer
      • Parathyroid Tumour
        • Parathyroid Tumour - Conditions to consider
        • Parathyroid Tumour
      • Phaeochromocytoma or Paraganglioma
        • Phaeochromocytoma or Paraganglioma - Conditions to consider
        • Phaeochromocytoma or Paraganglioma
      • Pituitary Tumour
        • Pituitary Tumour - Conditions to consider
        • Pituitary Tumour
      • Thyroid Cancer
        • Thyroid Cancer - Conditions to consider
        • Thyroid Cancer
    • Childhood Cancer
      • Childhood Cancer - Conditions to consider
      • Childhood Cancer
    • Sarcoma
      • Sarcoma - Conditions to consider
      • Sarcoma
    • Brain or Spinal Cord Tumour
      • Brain or Spinal Cord Tumour - Conditions to consider
      • Brain or Spinal Cord Tumour
  • Patient Without Cancer Diagnosis
    • Multiple Cancer/Tumour Types - Family History
    • Breast Cancer - Family History
      • Breast Cancer - Family History - Conditions to consider
      • Female Breast Cancer (unilateral) - Family History
      • Female Breast Cancer (bilateral) - Family History
      • Male Breast Cancer - Family History
      • Breast and Ovarian Cancer - Family History
    • Gastrointestinal Cancer - Family History
      • Colorectal Cancer - Family History
        • Colorectal Cancer - Family History - Conditions to consider
        • Colorectal Cancer - Family History
      • Liver Cancer - Family History
      • Oesophagogastric Cancer - Family History
        • Oesophagogastric Cancer - Family History - Conditions to consider
        • Oesophagogastric Cancer - Family History
      • Pancreatobiliary Cancer - Family History
        • Pancreatobiliary Cancer - Family History - Conditions to consider
        • Pancreatobiliary Cancer - Family History
      • Small Bowel Cancer - Family History
        • Small Bowel Cancer - Family History - Conditions to consider
        • Small Bowel Cancer - Family History
    • Lung Cancer - Family History
    • Gynaecological Cancer - Family History
      • Cervical Cancer - Family History
      • Endometrial Cancer - Family History
        • Endometrial Cancer - Family History - Conditions to consider
        • Endometrial Cancer - Family History
      • Ovarian, Fallopian tube or Primary Peritoneal Cancer - Family History
        • Ovarian, Fallopian tube or Primary Peritoneal Cancer - Family History - Conditions to consider
        • Ovarian, Fallopian tube or Primary Peritoneal Cancer - Family History
    • Genitourinary Cancer - Family History
      • Prostate Cancer - Family History
        • Prostate Cancer - Family History - Conditions to consider
        • Prostate Cancer - Family History
      • Renal Cell Cancer - Family History
        • Renal Cell Cancer - Family History - Conditions to consider
        • Renal Cell Cancer - Family History
      • Urinary Tract Cancer - Family History
        • Urinary Tract Cancer - Family History - Conditions to consider
        • Urinary Tract Cancer - Family History
    • Haematological Cancer - Family History
    • Skin Cancer/Tumour - Family History
    • Endocrine Cancer/Tumour - Family History
      • Adrenocortical Cancer - Family History
        • Adrenocortical Cancer - Family History - Conditions to consider
        • Adrenocortical Cancer - Family History
      • Parathyroid Tumour - Family History
        • Parathyroid Tumour - Family History - Conditions to consider
        • Parathyroid Tumour - Family History
      • Phaeochromocytoma or Paraganglioma - Family History
        • Phaeochromocytoma or Paraganglioma - Family History - Conditions to consider
        • Phaeochromocytoma or Paraganglioma - Family History
      • Pituitary Tumour - Family History
        • Pituitary Tumour - Family History - Conditions to consider
        • Pituitary Tumour - Family History
      • Thyroid Cancer - Family History
        • Thyroid Cancer - Family History - Conditions to consider
        • Thyroid Cancer - Family History
    • Childhood Cancer - Family History
    • Sarcoma - Family History
      • Sarcoma - Family History - Conditions to consider
      • Sarcoma - Family History
    • Brain or Spinal Cord Tumour - Family History

• Reference Guide
  • Hereditary Cancer Conditions
    • Hereditary Breast and Ovarian Cancer
    • Li-Fraumeni Syndrome
    • Cowden Syndrome
    • Lynch Syndrome
    • Familial Adenomatous Polyposis
    • MYH-associated Polyposis
    • Juvenile Polyposis Syndrome
    • Peutz-Jeghers Syndrome
    • Hereditary Mixed Polyposis Syndrome
    • Serrated Polyposis Syndrome
    • Hereditary Diffuse Gastric Cancer
    • Von-Hippel-Lindau Syndrome
    • Neurofibromatosis type 1
    • Neurofibromatosis type 2
    • Multiple Endocrine Neoplasia type 1
    • Multiple Endocrine Neoplasia type 2
    • Hereditary Phaeochromocytoma/Paraganglioma Syndrome
    • Familial Isolated Pituitary Adenomas
    • Hyperparathyroidism Jaw Tumour Syndrome
    • Familial Atypical Multiple Mole Melanoma Syndrome
    • Naevoid Basal Cell Carcinoma Syndrome
    • Birt-Hogg-Dube Syndrome
    • Hereditary Leiomyomatosis and Renal Cell Carcinoma
    • Hereditary Papillary Renal Cell Carcinoma
    • Familial Retinoblastoma
    • Familial Pleuropulmonaryblastoma Tumour Predisposition Syndrome
    • Rhabdoid Tumour Predisposition Syndrome
  • Syndromes associated with Cancer/Tumour Risk
    • Ataxia telangiectasia
    • Beckwith-Wiedemann Syndrome
    • Bloom Syndrome
    • Constitutional Mismatch Repair Deficiency
    • Fanconi Anaemia
    • Tuberous Sclerosis
    • Xeroderma Pigmentosum
  • Useful Links
    • Guy's Regional Genetics Service
    • British Society for Genetic Medicine
    • National Institute for Health and Care Excellence
    • National Genetics and Genomics Education Centre
    • Cancer Research UK
    • Gene Reviews
    • Genetics Home Reference
    • Genetic Alliance UK
    • Genomics England and 100,000 Genomes Project
    • London Cancer Alliance
    • Macmillan Cancer Support
    • Online Mendelian Inheritance in Man
    • UK Genetic Testing Network
  • Glossary
    • Amsterdam family history
    • Autosomal dominant
    • Autosomal recessive
    • Bethesda family history
    • Family relationships
    • Founder mutation
    • Gene mutations
    • Gene sequencing technologies
      • Array CGH (Comparative genomic hybridisation)
      • Exome sequencing
      • MLPA (Multiplex Ligation-dependent Probe Amplification)
      • Whole genome sequencing
    • Genetic heterogeneity
    • Genetic testing
    • High risk for Breast Cancer
    • High risk for Colorectal Cancer
    • High-Moderate risk for Colorectal Cancer
    • Inheritance
    • Low-Moderate risk for Colorectal Cancer
    • Microsatellite Instability
    • Moderate risk for Breast cancer
    • Mosaicism
    • Oncogenes and Tumour Suppressor genes
    • Preimplantation genetic diagnosis (PGD)
    • Triple-negative Breast Cancer
  • Patient Information Leaflets
  • Family History Questionnaire

• Contact Us

• User Feedback

• Copyright